Where Is The Evidence That Animal Research Benefits Humans?
Education And Debate Where is the testify that animal research benefits humans?
BMJ 2004; 328 doi: https://doi.org/10.1136/bmj.328.7438.514 (Published 26 Feb 2004) Cite this as: BMJ 2004;328:514
- Pandora Pound , enquiry fellow 1,
- Shah Ebrahim , professor 1,
- Peter Sandercock , professor 2,
- Michael B Bracken , professor 3,
- Ian Roberts , professor (Ian.Roberts@lshtm.air-conditioning.uk) four
- iDepartment of Social Medicine, University of Bristol, Bristol BS8 2PR
- twoDepartment of Clinical Neurosciences, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU
- 3Eye for Perinatal, Pediatric, and Environmental Epidemiology, Yale Academy School of Medicine, New Haven, CT 06520 Us
- fourLondon School of Hygiene and Tropical Medicine, London WC1B 3DP
- Correspondence to: I Roberts
Much animal research into potential treatments for humans is wasted considering it is poorly conducted and not evaluated through systematic reviews
Clinicians and the public oft consider it axiomatic that animal research has contributed to the treatment of homo disease, yet little testify is available to back up this view. Few methods exist for evaluating the clinical relevance or importance of bones animal research, and then its clinical (every bit distinct from scientific) contribution remains uncertain.i Anecdotal testify or unsupported claims are often used as justification—for example, statements that the need for animal research is "self evident"2 or that "Animate being experimentation is a valuable enquiry method which has proved itself over time."3 Such statements are an inadequate form of evidence for such a controversial area of enquiry. We argue that systematic reviews of existing and hereafter enquiry are needed.
Assessing animal research
Despite the lack of systematic prove for its effectiveness, basic brute research in the Britain receives much more funding than clinical enquiry.one 4 5 Given this, and because the public accepts fauna enquiry only on the assumption that it benefits humans,6 the clinical relevance of animal experiments needs urgent clarification.
Several methods are available to evaluate animal research. These include historical assay,7 critiques of animal models,8 investigations into the evolution of treatments,5 surveys of clinicians' views,nine and citation analyses.10 However, perhaps the best way of producing show about the value of animal research is to conduct systematic reviews of animate being studies and, where possible, compare the results of these with the results of the corresponding clinical trials. So what do studies that have done this show?
Systematic reviews of animal research
We searched Medline to identify published systematic reviews of animate being experiments (see bmj.com for the search strategy). The search identified 277 possible papers, of which 22 …
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Source: https://www.bmj.com/content/328/7438/514
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